Best Supplements for Antioxidant
6 evidence-based options for antioxidant, summarized from the research: what they do, how to dose them, and how they work together.
Coenzyme Q10 (CoQ10)
A mitochondrial antioxidant for cellular energy and heart health.
Copper
The trace mineral that balances zinc.
Curcumin
Turmeric's anti-inflammatory active compound.
NAC
A powerful antioxidant precursor and lung-health support compound.
Vitamin B2 (Riboflavin)
The flavin cofactor behind energy, antioxidant defence, and migraine prevention.
Vitamin C
Antioxidant vitamin and iron-absorption amplifier.
Where to buy for antioxidant
Our top options for this goal. Choose third-party-tested brands in the forms each supplement's page recommends.
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Combinations to know
How these supplements pair with each other and beyond.
Copper + NAC
NAC may chelate copper at high doses; monitor copper status with long-term high-dose NAC use.
NAC + Vitamin C
Vitamin C regenerates oxidised glutathione back to its active form, amplifying NAC's antioxidant effect.
Coenzyme Q10 (CoQ10) + NAC
Two antioxidants that defend mitochondria and cell membranes through complementary mechanisms.
Copper + Zinc
Long-term high-dose zinc depletes copper; pairing them (≈1 mg copper per 10–15 mg zinc) keeps the balance healthy.
Curcumin + Piperine
Piperine from black pepper can increase curcumin bioavailability dramatically (studies report up to ~20x).
Glycine + NAC
NAC provides cysteine while glycine provides another rate-limiting precursor; together they are more effective at raising glutathione than either alone (GlyNAC protocol).
Frequently asked questions
What are the best supplements for antioxidant?
The most-researched options are Coenzyme Q10 (CoQ10), Copper, Curcumin, NAC, Vitamin B2 (Riboflavin), and Vitamin C. Each is summarised with its benefits, typical dosing, and the strength of the evidence behind it.
How were these antioxidant supplements chosen?
These are the supplements in the Vital Matrix library most commonly used for antioxidant, graded by the strength of human evidence. See our methodology for how we grade the research.
Can you combine supplements for antioxidant?
Yes, several pair well. For example, Copper and NAC: NAC may chelate copper at high doses; monitor copper status with long-term high-dose NAC use.