Glycine and NAC
NAC provides cysteine while glycine provides another rate-limiting precursor; together they are more effective at raising glutathione than either alone (GlyNAC protocol).
Glycine
A calming amino acid for sleep, collagen, and metabolic health.
NAC
A powerful antioxidant precursor and lung-health support compound.
Great to combine
These two are frequently stacked together; they complement each other and are commonly taken at the same time.
How to take them
Glycine
- Dose
- 3 g before bed for sleep; up to 10 g/day for collagen support
- Timing
- 30–60 minutes before bed for sleep; with meals for collagen/metabolic goals
NAC
- Dose
- 600–1,800 mg per day in divided doses
- Timing
- With food to reduce GI upset
Frequently asked
Can you take Glycine and NAC together?
Yes, they are commonly taken together. NAC provides cysteine while glycine provides another rate-limiting precursor; together they are more effective at raising glutathione than either alone (GlyNAC protocol).
What's the best time to take Glycine and NAC?
Around the same time works well. Glycine: 30–60 minutes before bed for sleep; with meals for collagen/metabolic goals. NAC: With food to reduce GI upset.
How do Glycine and NAC interact?
Synergy: Work better together than alone. NAC provides cysteine while glycine provides another rate-limiting precursor; together they are more effective at raising glutathione than either alone (GlyNAC protocol).
Related pairings
Glycine + Magnesium
A classic sleep stack: glycine lowers core body temperature while magnesium glycinate relaxes muscles and calms the nervous system.
Creatine + Glycine
Glycine is one of the three amino acids the body uses to synthesise creatine endogenously.
L-Glutamine + Glycine
Both are conditionally essential under stress and support gut and immune function through complementary pathways.
Glycine + L-Tryptophan
Glycine (inhibitory) and tryptophan-derived serotonin/melatonin work through complementary pathways to support sleep.