Best Supplements for Mood
4 evidence-based options for mood, summarized from the research: what they do, how to dose them, and how they work together.
Folate (B9)
The active B vitamin behind methylation, mood, and pregnancy health.
L-Tryptophan
The dietary precursor to serotonin and melatonin.
L-Tyrosine
The dopamine precursor that sharpens focus under stress.
Vitamin D3
The sunshine vitamin behind bone, immune, and mood health.
Combinations to know
How these supplements pair with each other and beyond.
Folate (B9) + L-Tryptophan
Folate supports the methylation cycle needed to recycle and activate neurotransmitter cofactors.
Folate (B9) + L-Tyrosine
Methylation via folate is required to activate cofactors in catecholamine synthesis.
Calcium + Vitamin D3
Vitamin D3 is required to absorb dietary and supplemental calcium.
Magnesium + Vitamin D3
Magnesium is required to convert vitamin D into its active form, so low magnesium blunts D3's benefits.
Vitamin D3 + Vitamin K2
K2 directs the calcium that D3 helps absorb into bone rather than soft tissue and arteries.
Folate (B9) + Iron
Both folate and iron are needed for healthy red blood cell production. Deficiency in either causes anaemia.