Best Supplements for Blood sugar
2 evidence-based options for blood sugar, summarized from the research: what they do, how to dose them, and how they work together.
Berberine
A plant alkaloid with drug-like effects on blood sugar.
Magnesium
A master mineral involved in 300+ enzyme reactions.
Where to buy for blood sugar
Our top options for this goal. Choose third-party-tested brands in the forms each supplement's page recommends.
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Combinations to know
How these supplements pair with each other and beyond.
Glycine + Magnesium
A sleep pairing with a built-in shortcut: magnesium glycinate is magnesium bound to glycine, so that form already delivers both. A standalone 3 g dose before bed (the amount sleep studies used) tops up the glycine, lowering core body temperature while magnesium relaxes muscles and calms the nervous system.
Magnesium + Vitamin D3
Magnesium is required to convert vitamin D into its active form, so low magnesium blunts D3's benefits.
L-Arginine + Magnesium
Magnesium supports vascular smooth muscle relaxation alongside nitric oxide from arginine.
Ashwagandha + Magnesium
Commonly combined for stress relief and better sleep quality.
Boron + Magnesium
Boron reduces urinary magnesium loss and supports magnesium status, complementing magnesium supplementation.
Folate (B9) + Magnesium
Magnesium is a required cofactor for many methylation enzymes; low magnesium can limit the benefit of folate supplementation.
Frequently asked questions
What are the best supplements for blood sugar?
The most-researched options are Berberine and Magnesium. Each is summarised with its benefits, typical dosing, and the strength of the evidence behind it.
How were these blood sugar supplements chosen?
These are the supplements in the Vital Matrix library most commonly used for blood sugar, graded by the strength of human evidence. See our methodology for how we grade the research.
Can you combine supplements for blood sugar?
Yes, several pair well. For example, Glycine and Magnesium: A sleep pairing with a built-in shortcut: magnesium glycinate is magnesium bound to glycine, so that form already delivers both. A standalone 3 g dose before bed (the amount sleep studies used) tops up the glycine, lowering core body temperature while magnesium relaxes muscles and calms the nervous system.