Best Supplements for Brain health
4 evidence-based options for brain health, summarized from the research: what they do, how to dose them, and how they work together.
Folate (B9)
The active B vitamin behind methylation, mood, and pregnancy health.
L-Tyrosine
The dopamine precursor that sharpens focus under stress.
NAC
A powerful antioxidant precursor and lung-health support compound.
Omega-3 (Fish Oil)
Anti-inflammatory fats for heart, brain, and joints.
Combinations to know
How these supplements pair with each other and beyond.
Folate (B9) + L-Tyrosine
Methylation via folate is required to activate cofactors in catecholamine synthesis.
Glycine + NAC
NAC provides cysteine while glycine provides another rate-limiting precursor; together they are more effective at raising glutathione than either alone (GlyNAC protocol).
Folate (B9) + Iron
Both folate and iron are needed for healthy red blood cell production. Deficiency in either causes anaemia.
Folate (B9) + Magnesium
Magnesium is a required cofactor for many methylation enzymes; low magnesium can limit the benefit of folate supplementation.
Folate (B9) + L-Tryptophan
Folate supports the methylation cycle needed to recycle and activate neurotransmitter cofactors.
Caffeine + L-Tyrosine
Tyrosine and caffeine are commonly stacked for sustained focus; tyrosine may offset the catecholamine depletion that follows caffeine's stimulant effect.