Best Supplements for Pregnancy
2 evidence-based options for pregnancy, summarized from the research: what they do, how to dose them, and how they work together.
Folate (B9)
The active B vitamin behind methylation, mood, and pregnancy health.
Vitamin B12 (Cobalamin)
The methylation and nerve-health vitamin that protects the brain and blood.
Combinations to know
How these supplements pair with each other and beyond.
Folate (B9) + Vitamin B12 (Cobalamin)
Folate and B12 work as a pair in the methylation cycle. B12 is required for folate to re-enter active circulation; deficiency in either disrupts both.
Folate (B9) + TMG (Trimethylglycine)
TMG provides a folate-independent route to remethylate homocysteine (via BHMT), complementing the folate/B12 pathway, useful when folate cycling is impaired.
Folate (B9) + Vitamin B6 (Pyridoxine)
B6 and folate work together to lower homocysteine and support methylation balance.
Vitamin B12 (Cobalamin) + Vitamin B6 (Pyridoxine)
B6, B12, and folate form the homocysteine-methylation trio; imbalance in any one disrupts the others.
Folate (B9) + Iron
Both folate and iron are needed for healthy red blood cell production. Deficiency in either causes anaemia.
Folate (B9) + Magnesium
Magnesium is a required cofactor for many methylation enzymes; low magnesium can limit the benefit of folate supplementation.
Frequently asked questions
What are the best supplements for pregnancy?
The most-researched options are Folate (B9) and Vitamin B12 (Cobalamin). Each is summarised with its benefits, typical dosing, and the strength of the evidence behind it.
How were these pregnancy supplements chosen?
These are the supplements in the Vital Matrix library most commonly used for pregnancy, graded by the strength of human evidence. See our methodology for how we grade the research.
Can you combine supplements for pregnancy?
Yes, several pair well. For example, Folate (B9) and Vitamin B12 (Cobalamin): Folate and B12 work as a pair in the methylation cycle. B12 is required for folate to re-enter active circulation; deficiency in either disrupts both.