Best Supplements for Liver health
2 evidence-based options for liver health, summarized from the research: what they do, how to dose them, and how they work together.
NAC
A powerful antioxidant precursor and lung-health support compound.
TMG (Trimethylglycine)
A methyl-donor cousin of glycine for homocysteine, liver, and power.
Combinations to know
How these supplements pair with each other and beyond.
Glycine + NAC
NAC provides cysteine while glycine provides another rate-limiting precursor; together they are more effective at raising glutathione than either alone (GlyNAC protocol).
Folate (B9) + TMG (Trimethylglycine)
TMG provides a folate-independent route to remethylate homocysteine (via BHMT), complementing the folate/B12 pathway, useful when folate cycling is impaired.
Copper + NAC
NAC may chelate copper at high doses; monitor copper status with long-term high-dose NAC use.
NAC + Vitamin C
Vitamin C regenerates oxidised glutathione back to its active form, amplifying NAC's antioxidant effect.
NAC + Zinc
NAC's chelating action can reduce zinc levels with high chronic doses; supplementing zinc alongside long-term NAC use is advisable.
Creatine + TMG (Trimethylglycine)
Creatine synthesis consumes a large share of the body's methyl groups; TMG helps replenish methylation capacity and both are studied for strength and power.
Frequently asked questions
What are the best supplements for liver health?
The most-researched options are NAC and TMG (Trimethylglycine). Each is summarised with its benefits, typical dosing, and the strength of the evidence behind it.
How were these liver health supplements chosen?
These are the supplements in the Vital Matrix library most commonly used for liver health, graded by the strength of human evidence. See our methodology for how we grade the research.
Can you combine supplements for liver health?
Yes, several pair well. For example, Glycine and NAC: NAC provides cysteine while glycine provides another rate-limiting precursor; together they are more effective at raising glutathione than either alone (GlyNAC protocol).