Creatine and TMG (Trimethylglycine)
Creatine synthesis consumes a large share of the body's methyl groups; TMG helps replenish methylation capacity and both are studied for strength and power.
Creatine
The most-studied performance and cognition supplement.
TMG (Trimethylglycine)
A methyl-donor cousin of glycine for homocysteine, liver, and power.
Great to combine
These two are frequently stacked together; they complement each other and are commonly taken at the same time.
How to take them
Creatine
- Dose
- 3–5 g of monohydrate per day
- Timing
- Any time daily; consistency matters more than timing. If you notice sleep disruption, take it earlier in the day.
TMG (Trimethylglycine)
- Dose
- 2.5 g/day for performance; 3–6 g/day studied for homocysteine
- Timing
- With meals; performance studies often split it into two daily doses
Frequently asked
Can you take Creatine and TMG (Trimethylglycine) together?
Yes, they are commonly taken together. Creatine synthesis consumes a large share of the body's methyl groups; TMG helps replenish methylation capacity and both are studied for strength and power.
What's the best time to take Creatine and TMG (Trimethylglycine)?
Around the same time works well. Creatine: Any time daily; consistency matters more than timing. If you notice sleep disruption, take it earlier in the day.. TMG (Trimethylglycine): With meals; performance studies often split it into two daily doses.
How do Creatine and TMG (Trimethylglycine) interact?
Synergy: Work better together than alone. Creatine synthesis consumes a large share of the body's methyl groups; TMG helps replenish methylation capacity and both are studied for strength and power.
Related pairings
Creatine + Glycine
Glycine is one of the three amino acids the body uses to synthesise creatine endogenously.
Creatine + L-Citrulline
A popular pre-workout pairing: citrulline for blood flow and pumps, creatine for power and strength output.
Caffeine + Creatine
Some early data hinted caffeine might blunt creatine's effects; evidence is mixed and any effect is likely minor.
Creatine + L-Glutamine
Common in post-workout recovery stacks; glutamine for gut integrity and creatine for muscle energy replenishment.