Folate (B9) and TMG (Trimethylglycine)
TMG provides a folate-independent route to remethylate homocysteine (via BHMT), complementing the folate/B12 pathway, useful when folate cycling is impaired.
Folate (B9)
The active B vitamin behind methylation, mood, and pregnancy health.
TMG (Trimethylglycine)
A methyl-donor cousin of glycine for homocysteine, liver, and power.
Great to combine
These two are frequently stacked together; they complement each other and are commonly taken at the same time.
How to take them
Folate (B9)
- Dose
- 400–1,000 mcg DFE per day; up to 1,000 mcg L-Methylfolate for MTHFR
- Timing
- With or without food; morning is common to support daytime methylation
TMG (Trimethylglycine)
- Dose
- 2.5 g/day for performance; 3–6 g/day studied for homocysteine
- Timing
- With meals; performance studies often split it into two daily doses
Frequently asked
Can you take Folate (B9) and TMG (Trimethylglycine) together?
Yes, they are commonly taken together. TMG provides a folate-independent route to remethylate homocysteine (via BHMT), complementing the folate/B12 pathway, useful when folate cycling is impaired.
What's the best time to take Folate (B9) and TMG (Trimethylglycine)?
Around the same time works well. Folate (B9): With or without food; morning is common to support daytime methylation. TMG (Trimethylglycine): With meals; performance studies often split it into two daily doses.
How do Folate (B9) and TMG (Trimethylglycine) interact?
Synergy: Work better together than alone. TMG provides a folate-independent route to remethylate homocysteine (via BHMT), complementing the folate/B12 pathway, useful when folate cycling is impaired.
Related pairings
Folate (B9) + Vitamin B12 (Cobalamin)
Folate and B12 work as a pair in the methylation cycle. B12 is required for folate to re-enter active circulation; deficiency in either disrupts both.
Folate (B9) + Vitamin B6 (Pyridoxine)
B6 and folate work together to lower homocysteine and support methylation balance.
Folate (B9) + Iron
Both folate and iron are needed for healthy red blood cell production. Deficiency in either causes anaemia.
Folate (B9) + Magnesium
Magnesium is a required cofactor for many methylation enzymes; low magnesium can limit the benefit of folate supplementation.