Folate (B9) and L-Tyrosine
Methylation via folate is required to activate cofactors in catecholamine synthesis.
Folate (B9)
The active B vitamin behind methylation, mood, and pregnancy health.
L-Tyrosine
The dopamine precursor that sharpens focus under stress.
Designed to work as a pair
One is required for the other to do its job, so they belong together in a stack.
How to take them
Folate (B9)
- Dose
- 400–1,000 mcg DFE per day; up to 1,000 mcg L-Methylfolate for MTHFR
- Timing
- With or without food; morning is common to support daytime methylation
L-Tyrosine
- Dose
- 500–2,000 mg taken 30–60 minutes before a stressful task or period of sleep deprivation
- Timing
- On an empty stomach, 30–60 min before the stressful event
Frequently asked
Can you take Folate (B9) and L-Tyrosine together?
Yes, they are commonly taken together. Methylation via folate is required to activate cofactors in catecholamine synthesis.
What's the best time to take Folate (B9) and L-Tyrosine?
Around the same time works well. Folate (B9): With or without food; morning is common to support daytime methylation. L-Tyrosine: On an empty stomach, 30–60 min before the stressful event.
How do Folate (B9) and L-Tyrosine interact?
Cofactor: Required for the other to do its job. Methylation via folate is required to activate cofactors in catecholamine synthesis.
Related pairings
Folate (B9) + Iron
Both folate and iron are needed for healthy red blood cell production. Deficiency in either causes anaemia.
Folate (B9) + Magnesium
Magnesium is a required cofactor for many methylation enzymes; low magnesium can limit the benefit of folate supplementation.
Folate (B9) + L-Tryptophan
Folate supports the methylation cycle needed to recycle and activate neurotransmitter cofactors.
Caffeine + L-Tyrosine
Tyrosine and caffeine are commonly stacked for sustained focus; tyrosine may offset the catecholamine depletion that follows caffeine's stimulant effect.