Folate (B9) and Vitamin B2 (Riboflavin)
Riboflavin is required to convert folate into its active 5-MTHF form.
Folate (B9)
The active B vitamin behind methylation, mood, and pregnancy health.
Vitamin B2 (Riboflavin)
The flavin cofactor behind energy, antioxidant defence, and migraine prevention.
Designed to work as a pair
One is required for the other to do its job, so they belong together in a stack.
How to take them
Folate (B9)
- Dose
- 400–1,000 mcg DFE per day; up to 1,000 mcg L-Methylfolate for MTHFR
- Timing
- With or without food; morning is common to support daytime methylation
Vitamin B2 (Riboflavin)
- Dose
- 1–1.5 mg RDA; 200–400 mg for migraine prevention
- Timing
- Morning or divided with meals; high doses with food
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Folate
Vitamin B2
Frequently asked
Can you take Folate (B9) and Vitamin B2 (Riboflavin) together?
Yes, they are commonly taken together. Riboflavin is required to convert folate into its active 5-MTHF form.
What's the best time to take Folate (B9) and Vitamin B2 (Riboflavin)?
Around the same time works well. Folate (B9): With or without food; morning is common to support daytime methylation. Vitamin B2 (Riboflavin): Morning or divided with meals; high doses with food.
How do Folate (B9) and Vitamin B2 (Riboflavin) interact?
Cofactor: Required for the other to do its job. Riboflavin is required to convert folate into its active 5-MTHF form.
Related pairings
Folate (B9) + TMG (Trimethylglycine)
TMG provides a folate-independent route to remethylate homocysteine (via BHMT), complementing the folate/B12 pathway, useful when folate cycling is impaired.
Folate (B9) + Vitamin B12 (Cobalamin)
Folate and B12 work as a pair in the methylation cycle. B12 is required for folate to re-enter active circulation; deficiency in either disrupts both.
Folate (B9) + Vitamin B6 (Pyridoxine)
B6 and folate work together to lower homocysteine and support methylation balance.
Folate (B9) + Iron
Both folate and iron are needed for healthy red blood cell production. Deficiency in either causes anaemia.