TMG (Trimethylglycine) and Vitamin B12 (Cobalamin)
Both feed the homocysteine-methylation cycle through parallel routes; TMG can pick up remethylation when B12-dependent methionine synthase is limited.
TMG (Trimethylglycine)
A methyl-donor cousin of glycine for homocysteine, liver, and power.
Vitamin B12 (Cobalamin)
The methylation and nerve-health vitamin that protects the brain and blood.
Great to combine
These two are frequently stacked together; they complement each other and are commonly taken at the same time.
How to take them
TMG (Trimethylglycine)
- Dose
- 2.5 g/day for performance; 3–6 g/day studied for homocysteine
- Timing
- With meals; performance studies often split it into two daily doses
Vitamin B12 (Cobalamin)
- Dose
- 2.4 mcg RDA; 500–1,000 mcg for deficiency or vegan diets; 1,000 mcg weekly injections if malabsorption
- Timing
- Morning or any time; sublingual forms may be taken without food
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Frequently asked
Can you take TMG (Trimethylglycine) and Vitamin B12 (Cobalamin) together?
Yes, they are commonly taken together. Both feed the homocysteine-methylation cycle through parallel routes; TMG can pick up remethylation when B12-dependent methionine synthase is limited.
What's the best time to take TMG (Trimethylglycine) and Vitamin B12 (Cobalamin)?
Around the same time works well. TMG (Trimethylglycine): With meals; performance studies often split it into two daily doses. Vitamin B12 (Cobalamin): Morning or any time; sublingual forms may be taken without food.
How do TMG (Trimethylglycine) and Vitamin B12 (Cobalamin) interact?
Synergy: Work better together than alone. Both feed the homocysteine-methylation cycle through parallel routes; TMG can pick up remethylation when B12-dependent methionine synthase is limited.
Related pairings
Folate (B9) + TMG (Trimethylglycine)
TMG provides a folate-independent route to remethylate homocysteine (via BHMT), complementing the folate/B12 pathway, useful when folate cycling is impaired.
Creatine + TMG (Trimethylglycine)
Creatine synthesis consumes a large share of the body's methyl groups; TMG helps replenish methylation capacity and both are studied for strength and power.
Glycine + TMG (Trimethylglycine)
Structurally glycine plus three methyl groups, but functionally distinct: TMG donates methyls (becoming dimethylglycine) while glycine can accept them, together they help buffer methylation balance.
Folate (B9) + Vitamin B12 (Cobalamin)
Folate and B12 work as a pair in the methylation cycle. B12 is required for folate to re-enter active circulation; deficiency in either disrupts both.