Glycine and TMG (Trimethylglycine)
Structurally glycine plus three methyl groups, but functionally distinct: TMG donates methyls (becoming dimethylglycine) while glycine can accept them, together they help buffer methylation balance.
Glycine
A calming amino acid for sleep, collagen, and metabolic health.
TMG (Trimethylglycine)
A methyl-donor cousin of glycine for homocysteine, liver, and power.
Great to combine
These two are frequently stacked together; they complement each other and are commonly taken at the same time.
How to take them
Glycine
- Dose
- 3 g before bed for sleep; up to 10 g/day for collagen support
- Timing
- 30–60 minutes before bed for sleep; with meals for collagen/metabolic goals
TMG (Trimethylglycine)
- Dose
- 2.5 g/day for performance; 3–6 g/day studied for homocysteine
- Timing
- With meals; performance studies often split it into two daily doses
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Frequently asked
Can you take Glycine and TMG (Trimethylglycine) together?
Yes, they are commonly taken together. Structurally glycine plus three methyl groups, but functionally distinct: TMG donates methyls (becoming dimethylglycine) while glycine can accept them, together they help buffer methylation balance.
What's the best time to take Glycine and TMG (Trimethylglycine)?
Around the same time works well. Glycine: 30–60 minutes before bed for sleep; with meals for collagen/metabolic goals. TMG (Trimethylglycine): With meals; performance studies often split it into two daily doses.
How do Glycine and TMG (Trimethylglycine) interact?
Synergy: Work better together than alone. Structurally glycine plus three methyl groups, but functionally distinct: TMG donates methyls (becoming dimethylglycine) while glycine can accept them, together they help buffer methylation balance.
Related pairings
Glycine + Magnesium
A sleep pairing with a built-in shortcut: magnesium glycinate is magnesium bound to glycine, so that form already delivers both. A standalone 3 g dose before bed (the amount sleep studies used) tops up the glycine, lowering core body temperature while magnesium relaxes muscles and calms the nervous system.
Glycine + NAC
NAC provides cysteine while glycine provides another rate-limiting precursor; together they are more effective at raising glutathione than either alone (GlyNAC protocol).
Collagen + Glycine
Glycine makes up about a third of collagen, so supplementing it provides raw material that collagen synthesis depends on.
Creatine + Glycine
Glycine is one of the three amino acids the body uses to synthesise creatine endogenously.