Hydroxocobalamin
Also called Hydroxo B12
Hydroxocobalamin is a natural, stable form of B12 that the body converts to active forms. It tends to be retained longer in the body than cyanocobalamin and is less stimulating than methylcobalamin, making it a good option for people who feel agitated on methylated B vitamins. It is commonly used in injectable B12 therapies.
Best for
People who react to methylcobalamin or need longer-lasting stores
Absorption
High
Tolerability
Very well tolerated
Typical timing
Morning or any time; sublingual forms may be taken without food
How to take Hydroxocobalamin
A typical dose of Vitamin B12 (Cobalamin): 2.4 mcg RDA; 500–1,000 mcg for deficiency or vegan diets; 1,000 mcg weekly injections if malabsorption. Best timing: Morning or any time; sublingual forms may be taken without food. The form you choose mainly affects absorption and how easily it sits with your stomach, not the overall dose.