Hydroxocobalamin
Also called Hydroxo B12
Hydroxocobalamin is a natural, stable form of B12 that the body converts to active forms. It tends to be retained longer in the body than cyanocobalamin and is less stimulating than methylcobalamin, making it a good option for people who feel agitated on methylated B vitamins. It is commonly used in injectable B12 therapies.
Best for
People who react to methylcobalamin or need longer-lasting stores
Absorption
High
Tolerability
Very well tolerated
Typical timing
Morning or any time; sublingual forms may be taken without food
How to take Hydroxocobalamin
A typical dose of Vitamin B12 (Cobalamin): 2.4 mcg RDA; 500–1,000 mcg for deficiency or vegan diets; 1,000 mcg weekly injections if malabsorption. Best timing: Morning or any time; sublingual forms may be taken without food. The form you choose mainly affects absorption and how easily it sits with your stomach, not the overall dose.
Where to buy Hydroxocobalamin
Choose a third-party-tested brand; the label should name this form explicitly.
Some links below are affiliate links: if you buy through them we may earn a small commission at no extra cost to you. It never changes our ratings or evidence grades.