Cyanocobalamin
Also called Standard B12
Cyanocobalamin is the most common and stable form of B12 in supplements and fortified foods. The body converts it to methylcobalamin and adenosylcobalamin. A small cyanide group is released during metabolism, which is normally handled by detoxification pathways. It is effective for most people, though active forms are preferred for those with genetic or absorption issues.
Best for
Cost-effective deficiency correction in people with normal conversion
Absorption
High
Tolerability
Well tolerated; very stable
Typical timing
Morning or any time; sublingual forms may be taken without food
How to take Cyanocobalamin
A typical dose of Vitamin B12 (Cobalamin): 2.4 mcg RDA; 500–1,000 mcg for deficiency or vegan diets; 1,000 mcg weekly injections if malabsorption. Best timing: Morning or any time; sublingual forms may be taken without food. The form you choose mainly affects absorption and how easily it sits with your stomach, not the overall dose.