Adenosylcobalamin
Also called Dibencozide / Mitochondrial B12
Adenosylcobalamin is the mitochondrial form of B12 and is a cofactor for methylmalonyl-CoA mutase. It is particularly relevant for energy production and is often combined with methylcobalamin in high-quality B12 supplements. Evidence is less extensive than methylcobalamin, but it is biologically active and useful for people with mitochondrial concerns.
Best for
Energy and mitochondrial function
Absorption
High
Tolerability
Well tolerated
Typical timing
Morning or any time; sublingual forms may be taken without food
How to take Adenosylcobalamin
A typical dose of Vitamin B12 (Cobalamin): 2.4 mcg RDA; 500–1,000 mcg for deficiency or vegan diets; 1,000 mcg weekly injections if malabsorption. Best timing: Morning or any time; sublingual forms may be taken without food. The form you choose mainly affects absorption and how easily it sits with your stomach, not the overall dose.