Creatine and Glycine
Glycine is one of the three amino acids the body uses to synthesise creatine endogenously.
Creatine
The most-studied performance and cognition supplement.
Glycine
A calming amino acid for sleep, collagen, and metabolic health.
Designed to work as a pair
One is required for the other to do its job, so they belong together in a stack.
How to take them
Creatine
- Dose
- 3–5 g of monohydrate per day
- Timing
- Any time daily; consistency matters more than timing
Glycine
- Dose
- 3 g before bed for sleep; up to 10 g/day for collagen support
- Timing
- 30–60 minutes before bed for sleep; with meals for collagen/metabolic goals
Frequently asked
Can you take Creatine and Glycine together?
Yes, they are commonly taken together. Glycine is one of the three amino acids the body uses to synthesise creatine endogenously.
What's the best time to take Creatine and Glycine?
Around the same time works well. Creatine: Any time daily; consistency matters more than timing. Glycine: 30–60 minutes before bed for sleep; with meals for collagen/metabolic goals.
How do Creatine and Glycine interact?
Cofactor: Required for the other to do its job. Glycine is one of the three amino acids the body uses to synthesise creatine endogenously.
Related pairings
Creatine + L-Citrulline
A popular pre-workout pairing: citrulline for blood flow and pumps, creatine for power and strength output.
Caffeine + Creatine
Some early data hinted caffeine might blunt creatine's effects; evidence is mixed and any effect is likely minor.
Creatine + L-Glutamine
Common in post-workout recovery stacks; glutamine for gut integrity and creatine for muscle energy replenishment.
Glycine + Magnesium
A classic sleep stack: glycine lowers core body temperature while magnesium glycinate relaxes muscles and calms the nervous system.