L-Glutamine and Glycine
Both are conditionally essential under stress and support gut and immune function through complementary pathways.
L-Glutamine
The gut-lining repair amino acid and immune fuel.
Glycine
A calming amino acid for sleep, collagen, and metabolic health.
Great to combine
These two are frequently stacked together; they complement each other and are commonly taken at the same time.
How to take them
L-Glutamine
- Dose
- 5–15 g per day
- Timing
- With meals or post-workout for gut support; spread across the day
Glycine
- Dose
- 3 g before bed for sleep; up to 10 g/day for collagen support
- Timing
- 30–60 minutes before bed for sleep; with meals for collagen/metabolic goals
Buying L-Glutamine and Glycine?
Choose third-party-tested brands in the forms we recommend on each supplement's page.
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Frequently asked
Can you take L-Glutamine and Glycine together?
Yes, they are commonly taken together. Both are conditionally essential under stress and support gut and immune function through complementary pathways.
What's the best time to take L-Glutamine and Glycine?
Around the same time works well. L-Glutamine: With meals or post-workout for gut support; spread across the day. Glycine: 30–60 minutes before bed for sleep; with meals for collagen/metabolic goals.
How do L-Glutamine and Glycine interact?
Synergy: Work better together than alone. Both are conditionally essential under stress and support gut and immune function through complementary pathways.
Related pairings
L-Glutamine + Probiotics
Glutamine restores the gut lining while probiotics help balance the microbiome, a complementary gut-health stack.
Creatine + L-Glutamine
Common in post-workout recovery stacks; glutamine for gut integrity and creatine for muscle energy replenishment.
L-Glutamine + Inulin
Glutamine helps restore the gut lining while inulin feeds beneficial bacteria, a complementary gut-health stack.
Glycine + Magnesium
A sleep pairing with a built-in shortcut: magnesium glycinate is magnesium bound to glycine, so that form already delivers both. A standalone 3 g dose before bed (the amount sleep studies used) tops up the glycine, lowering core body temperature while magnesium relaxes muscles and calms the nervous system.