Creatine and L-Citrulline
A popular pre-workout pairing: citrulline for blood flow and pumps, creatine for power and strength output.
Creatine
The most-studied performance and cognition supplement.
L-Citrulline
A superior nitric oxide booster that outperforms arginine for pumps and endurance.
Great to combine
These two are frequently stacked together; they complement each other and are commonly taken at the same time.
How to take them
Creatine
- Dose
- 3–5 g of monohydrate per day
- Timing
- Any time daily; consistency matters more than timing. If you notice sleep disruption, take it earlier in the day.
L-Citrulline
- Dose
- 6–8 g citrulline malate (2:1) or 3–4 g pure L-Citrulline, 30–60 min pre-workout
- Timing
- 30–60 minutes before exercise
Buying Creatine and L-Citrulline?
Choose third-party-tested brands in the forms we recommend on each supplement's page.
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Frequently asked
Can you take Creatine and L-Citrulline together?
Yes, they are commonly taken together. A popular pre-workout pairing: citrulline for blood flow and pumps, creatine for power and strength output.
What's the best time to take Creatine and L-Citrulline?
Around the same time works well. Creatine: Any time daily; consistency matters more than timing. If you notice sleep disruption, take it earlier in the day.. L-Citrulline: 30–60 minutes before exercise.
How do Creatine and L-Citrulline interact?
Synergy: Work better together than alone. A popular pre-workout pairing: citrulline for blood flow and pumps, creatine for power and strength output.
Related pairings
Creatine + Glycine
Glycine is one of the three amino acids the body uses to synthesise creatine endogenously.
Creatine + TMG (Trimethylglycine)
Creatine synthesis consumes a large share of the body's methyl groups; TMG helps replenish methylation capacity and both are studied for strength and power.
Caffeine + Creatine
Some early data hinted caffeine might blunt creatine's effects; evidence is mixed and any effect is likely minor.
Coenzyme Q10 (CoQ10) + Creatine
Both support cellular ATP production in muscle and brain, complementing each other for energy and performance.