Vitamins

Benfotiamine

Also called S-benzoylthiamine O-monophosphate

Benfotiamine is a lipid-soluble thiamine derivative that crosses cell membranes more readily than water-soluble thiamine. It has been studied for diabetic neuropathy, vascular health, and advanced glycation end-product inhibition. It is not a better choice for simple energy support, but it is useful for targeted nerve and metabolic applications.

Best for

Nerve health, advanced glycation end-product concerns

Absorption

High

Tolerability

Generally well tolerated

Typical timing

With meals to improve absorption

How to take Benfotiamine

A typical dose of Vitamin B1 (Thiamine): 1–1.5 mg per day (RDA); 100–300 mg for therapeutic use. Best timing: With meals to improve absorption. The form you choose mainly affects absorption and how easily it sits with your stomach, not the overall dose.

Where to buy Benfotiamine

Choose a third-party-tested brand; the label should name this form explicitly.

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Benfotiamine vs other Vitamin B1 (Thiamine) forms