Piperine
Also known as Black pepper extract, BioPerine
Piperine is the pungent alkaloid in black pepper. On its own it has modest effects, but it shines as a bioavailability enhancer — most famously multiplying the absorption of curcumin by inhibiting its rapid breakdown.
Benefits
Enhances nutrient absorption
ModerateInhibits enzymes that break down certain compounds, increasing their bioavailability.
Pros & cons
Pros
- Tiny doses are effective
- Dramatically improves curcumin uptake
Cons
- Can alter medication levels
- Little standalone benefit
Side effects
Affects drug metabolism
Because it inhibits metabolizing enzymes, it can raise levels of some medications.
How to take it
Typical dose
5–20 mg per day (often bundled with curcumin)
Timing
Taken with the compound it is meant to enhance
Common forms
What the research says
Piperine as a bioavailability enhancer
ModerateIncreases absorption of several nutrients and drugs by inhibiting their metabolism and transport.
How it connects
Relationships between Piperine and other supplements in the matrix.
The signature pairing — piperine keeps curcumin in circulation long enough to act.
Compare the pairingImportant cautions
- Can increase blood levels of some prescription drugs — check interactions.