Berberine HCl
The hydrochloride salt used in virtually all of the research. Absorption is low, which is why doses are split across meals, but it has by far the deepest evidence base and the lowest cost.
Best for
Most people — the form used in nearly all clinical trials
Absorption
Low
Tolerability
GI upset is common at higher doses
Typical timing
With meals, to blunt post-meal glucose and reduce stomach upset
How to take Berberine HCl
A typical dose of Berberine: 500 mg two to three times daily (1,000–1,500 mg per day). Best timing: With meals, to blunt post-meal glucose and reduce stomach upset. The form you choose mainly affects absorption and how easily it sits with your stomach, not the overall dose.
Where to buy Berberine HCl
Choose a third-party-tested brand; the label should name this form explicitly.
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