Synergy

Vitamin D3 and Vitamin K2

K2 directs the calcium that D3 helps absorb into bone rather than soft tissue and arteries.

By the Vital Matrix Editorial TeamReviewed by the Vital Matrix Research TeamLast updated June 25, 2026

Great to combine

These two are frequently stacked together; they complement each other and are commonly taken at the same time.

How to take them

Vitamin D3

Dose
1,000–4,000 IU per day for most adults
Timing
With a meal containing fat for best absorption

Vitamin K2

Dose
90–180 mcg per day (MK-7) or 45–90 mg per day (MK-4)
Timing
With a fat-containing meal, often alongside D3

Buying Vitamin D3 and Vitamin K2?

Choose third-party-tested brands in the forms we recommend on each supplement's page.

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Frequently asked

Can you take Vitamin D3 and Vitamin K2 together?

Yes, they are commonly taken together. K2 directs the calcium that D3 helps absorb into bone rather than soft tissue and arteries.

What's the best time to take Vitamin D3 and Vitamin K2?

Around the same time works well. Vitamin D3: With a meal containing fat for best absorption. Vitamin K2: With a fat-containing meal, often alongside D3.

How do Vitamin D3 and Vitamin K2 interact?

Synergy: Work better together than alone. K2 directs the calcium that D3 helps absorb into bone rather than soft tissue and arteries.

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