Cofactor

Magnesium and Vitamin B1 (Thiamine)

Magnesium is required for thiamine-dependent enzymes to function properly.

By the Vital Matrix Editorial TeamReviewed by the Vital Matrix Research TeamLast updated June 25, 2026

Designed to work as a pair

One is required for the other to do its job, so they belong together in a stack.

How to take them

Magnesium

Dose
200–400 mg elemental magnesium per day
Timing
Evening for sleep support; with food to reduce GI upset

Vitamin B1 (Thiamine)

Dose
1–1.5 mg per day (RDA); 100–300 mg for therapeutic use
Timing
With meals to improve absorption

Frequently asked

Can you take Magnesium and Vitamin B1 (Thiamine) together?

Yes, they are commonly taken together. Magnesium is required for thiamine-dependent enzymes to function properly.

What's the best time to take Magnesium and Vitamin B1 (Thiamine)?

Around the same time works well. Magnesium: Evening for sleep support; with food to reduce GI upset. Vitamin B1 (Thiamine): With meals to improve absorption.

How do Magnesium and Vitamin B1 (Thiamine) interact?

Cofactor: Required for the other to do its job. Magnesium is required for thiamine-dependent enzymes to function properly.

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