Citicoline and Phosphatidylserine (PS)
Both support neuronal membrane synthesis through complementary phospholipid and cholinergic pathways.
Citicoline
A choline source studied for focus, memory, and brain health.
Phosphatidylserine (PS)
A brain-cell phospholipid studied for memory and stress.
Great to combine
These two are frequently stacked together; they complement each other and are commonly taken at the same time.
How to take them
Citicoline
- Dose
- 250–500 mg per day (up to 2,000 mg in clinical studies)
- Timing
- In the morning or early afternoon, with or without food
Phosphatidylserine (PS)
- Dose
- 100 mg three times daily (300 mg/day) for cognition
- Timing
- With meals; athletes often dose around training
Frequently asked
Can you take Citicoline and Phosphatidylserine (PS) together?
Yes, they are commonly taken together. Both support neuronal membrane synthesis through complementary phospholipid and cholinergic pathways.
What's the best time to take Citicoline and Phosphatidylserine (PS)?
Around the same time works well. Citicoline: In the morning or early afternoon, with or without food. Phosphatidylserine (PS): With meals; athletes often dose around training.
How do Citicoline and Phosphatidylserine (PS) interact?
Synergy: Work better together than alone. Both support neuronal membrane synthesis through complementary phospholipid and cholinergic pathways.
Related pairings
Citicoline + Uridine
Citicoline supplies choline while uridine supplies the nucleotide; combined with omega-3 DHA they form the classic membrane-synthesis stack.
Alpha-GPC + Citicoline
Both are bioavailable choline sources that raise acetylcholine; alpha-GPC delivers more choline by weight while citicoline also provides cytidine for membrane synthesis.
Citicoline + Huperzine A
Citicoline raises the supply of acetylcholine while huperzine A slows its breakdown, a complementary cholinergic pairing.
Citicoline + Omega-3 (Fish Oil)
DHA and a choline source like citicoline are used together to build neuronal membrane phospholipids.