Synergy

Ashwagandha and Phosphatidylserine (PS)

Both can blunt the cortisol stress response, a common pairing for stress resilience and recovery.

By the Vital Matrix Editorial TeamReviewed by the Vital Matrix Research TeamLast updated June 25, 2026

Great to combine

These two are frequently stacked together; they complement each other and are commonly taken at the same time.

How to take them

Ashwagandha

Dose
300–600 mg of a standardized extract per day
Timing
Evening for sleep, or split morning/evening for stress

Phosphatidylserine (PS)

Dose
100 mg three times daily (300 mg/day) for cognition
Timing
With meals; athletes often dose around training

Frequently asked

Can you take Ashwagandha and Phosphatidylserine (PS) together?

Yes, they are commonly taken together. Both can blunt the cortisol stress response, a common pairing for stress resilience and recovery.

What's the best time to take Ashwagandha and Phosphatidylserine (PS)?

Around the same time works well. Ashwagandha: Evening for sleep, or split morning/evening for stress. Phosphatidylserine (PS): With meals; athletes often dose around training.

How do Ashwagandha and Phosphatidylserine (PS) interact?

Synergy: Work better together than alone. Both can blunt the cortisol stress response, a common pairing for stress resilience and recovery.

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