Alpha-GPC and Phosphatidylserine (PS)
Both supply phospholipid and choline building blocks that support membranes and cholinergic signaling for cognition.
Alpha-GPC
A highly bioavailable choline source for memory and power output.
Phosphatidylserine (PS)
A brain-cell phospholipid studied for memory and stress.
Great to combine
These two are frequently stacked together; they complement each other and are commonly taken at the same time.
How to take them
Alpha-GPC
- Dose
- 300–600 mg per day (often 300 mg pre-workout)
- Timing
- With or without food; pre-workout for power output or in the morning for focus
Phosphatidylserine (PS)
- Dose
- 100 mg three times daily (300 mg/day) for cognition
- Timing
- With meals; athletes often dose around training
Frequently asked
Can you take Alpha-GPC and Phosphatidylserine (PS) together?
Yes, they are commonly taken together. Both supply phospholipid and choline building blocks that support membranes and cholinergic signaling for cognition.
What's the best time to take Alpha-GPC and Phosphatidylserine (PS)?
Around the same time works well. Alpha-GPC: With or without food; pre-workout for power output or in the morning for focus. Phosphatidylserine (PS): With meals; athletes often dose around training.
How do Alpha-GPC and Phosphatidylserine (PS) interact?
Synergy: Work better together than alone. Both supply phospholipid and choline building blocks that support membranes and cholinergic signaling for cognition.
Related pairings
Alpha-GPC + Caffeine
Commonly paired pre-workout and in focus stacks; alpha-GPC supports power output and acetylcholine while caffeine adds stimulation.
Alpha-GPC + Citicoline
Both are bioavailable choline sources that raise acetylcholine; alpha-GPC delivers more choline by weight while citicoline also provides cytidine for membrane synthesis.
Alpha-GPC + Huperzine A
A classic cholinergic stack: alpha-GPC supplies the choline to build acetylcholine while huperzine A slows its breakdown.
Alpha-GPC + L-Tyrosine
Often combined in focus formulas, pairing a choline source with a dopamine precursor for attention under demand.